Bioactive Small Molecules

A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.

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6,631 – 6,645 of 60,541 results

6,631

STEMCELL Technologies GW2580, Size: 25 mg

GW2580 is a selective inhibitor of cFMS kinase (IC₅₀ = 0.03 μM) (Conway et al., 2008), blocking its ability to autophosphorylate colony-stimulating factor (CSF-1 or M-CSF), which promotes the survival, proliferation, and differentiation of macrophages.DIFFERENTIATION· Demonstrates the importance of CSF-1 in promoting myeloid lineage bias in mouse hematopoietic stem cells (Mossadegh-Keller et al.).· Demonstrates the importance of CSF-1 in expansion of mouse and human macrophage colonies and monocytes (He et al.; Clanchy et al.; Conway et al., 2008; Conway et al., 2005).· Inhibits bone degradation in cultures of human osteoclasts, rat calvaria, and rat fetal long bone (Conway et al., 2005), and in mouse models of arthritis (Conway et al., 2008).

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6,632

Apexbio Technology LLC Pyrvinium Pamoate, 50mg CAS# 3546-41-6

Payrvinium pamoate is an ancient anthelmintic used to treat intestinal helminthiasis. As it inhibits the Wnt / -catenin pathway in certain types of cancer, it has attracted attention as an anticancer drug. In vitro, palmitate pyruvate treatment inhibited AKT-mediated phosphorylation of GSK3 at S9 and reduced the protein levels of -catenin and its downstream targets (c-Myc, cyclin D1). In addition, palmitate pyruvate significantly inhibited migration and invasion in vitro. Other sizes are also available. Please inqury us for quote.

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6,633

Medchemexpress LLC Diclosulam | 145701-21-9 | 98.2% | 500 MG

Diclosulam is a herbicide, also known by its synonym XDE 564. It is characterized by a Ki value of <32 nM and exhibits MIC and MIC50 values against CBS10913 and CBS12373 strains, ranging from 6.25 to 12.5 μM and 1.40 to 3.01 μM, respectively. Its applications extend to targeting acetohydroxyacid synthase.

Herbicide activity.
Potent inhibition of drug-resistant *Candida auris* growth.
Targets acetohydroxyacid synthase.
Available in solid appearance.
Purity of 98.20%.

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6,634

Cayman Chemical Atosiban, Purity: ≥98%, CAS: 90779-69-4, 25 mg

A peptide analog of oxytocin that antagonizes the human oxytocin receptor (Ki = 81 nM); has tocolytic actions in the acute phase of imminent preterm birth

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6,635

Cayman Chemical PX 1, Purity: ≥98%, CAS: 2221100-71-4, 10 mg

A derivative of AM2201 with a PINACA-like upper chain where the isopropyl group has been replaced with a benzyl group; intended for research and forensic applications

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6,636

Medchemexpress LLC 2,4(1H,3H)-Pyrimidinedione, 6-(octylamino)- | 83797-69-7 | 99.8% | 50 MG

6-OAU (6-n-octylaminouracil) is a GPR84 (G protein-coupled receptor 84) agonist with an EC50 value of 105 nM. It acts as a chemoattractant for both polymorphonuclear leukocytes (PMNs) and macrophages, amplifying the proinflammatory cytokine IL-8 and demonstrating proinflammatory activity. This compound also exhibits anti-bacterial functions.

Activates GPR84 with an EC50 of 105 nM in HEK293 cells.
Promotes PMN chemotaxis with an EC50 of 318 nM.
Increases IL-8 secretion from LPS-stimulated PMNs.
Amplifies TNF-α production from U937 macrophages.
Reduces ROS production during *B. abortus* infection.
Inhibits adhesion and *Brucella* uptake.
Displays anti-infection against *Brucella* and *Salmonella*.
Activates GPR84 leading to inflammatory conditions *in vivo*.
Augments resistance to *Brucella* infection and reduces bacterial proliferation *in vivo*.

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6,637

Cayman Chemical BB-22 4-hydroxyisoquinoline isomer, Purity: ≥98%, CAS: 2365471-21-0, 5 mg

Differs from BB-22 structurally by having an isoquinoline ring attached at the four position instead of a quinoline attached through the eight position of the ring; intended for forensic and research applications

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6,638

Cayman Chemical Hodgkinsine, Purity: ≥95%, CAS: 18210-71-4, 5 mg

An alkaloid with analgesic activity; increases latency to paw licking in the hot plate test and latency to tail withdrawal in the tail-flick test in mice at 5 mg/kg

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6,639

Cayman Chemical 3-Oxobetulin Acetate, Purity: ≥95%, CAS: 136587-07-0, 5 mg

A derivative of betulin; inhibits the growth of P388 cells (EC50 = 0.12 µg/ml), as well as MCF-7, SF-268, H460, and KM20L2 cells (GI50s = 8, 10.6, 5.2, and 12.7 µg/ml, respectively); inhibits replication of X4 tropic recombinant HIV (NL4.3-Ren) in MT-2 lymphoblastoid cells (IC50 = 13.4 µM); active against L. donovani amastigotes at 50 µM

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6,640

Cayman Chemical RU-505, Purity: ≥98%, CAS: 1314206-29-5, 1 mg

An inhibitor of the Aβ and fibrinogen interaction; has a higher efficacy for the monomer form of Aβ bound to fibrinogen over the oligomer form; normalizes fibrin clot formation disrupted by the Aβ42-fibrinogen interaction (20 µM); decreases the incidence of vessel occlusion in Tg6799 mice, a model of Alzheimer’s disease (35 mg/kg); decreases Aβ deposition in blood vessels and cortical fibrinogen infiltration and microgliosis in the brain of Tg6799 mice while improving spatial memory in chronically treated (35 mg/kg, s.c., every other day for 3 months) Tg6799 mice

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6,641

Medchemexpress LLC Soyasapogenol C | 595-14-2 | 5 MG

Soyasapogenol C is an oleanane-type triterpenoid that exhibits anti-HSV-1 activity with an IC50 of 18.9 μM. It is intended for research use only and is not sold to patients.

Oleanane-type triterpenoid
Exhibits anti-HSV-1 activity with an IC50 of 18.9 μM
No cytotoxicity at CC50 of 921 μM
Molecular weight: 440.70
Formula: C30H48O2
Appearance: White to off-white solid
For research use only
Store at 4°C, protected from light
Store in solvent at -80°C for 6 months or -20°C for 1 month, protected from light
Soluble in DMSO at 2.5 mg/mL (5.67 mM)

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6,642

Cayman Chemical HNMPA-(AM)3, Purity: ≥95%, CAS: 120944-03-8, 10 mg

A cell-permeable prodrug form of HNMPA; inhibits IRTK autophosphorylation in CHO cells expressing the human receptor in a concentration- and time-dependent manner; inhibits 2-deoxyglucose uptake but does not affect insulin-stimulated thymidine uptake in CHO cells (≤100 μM)

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6,643

Apexbio Technology LLC JNJ-26854165 (Serdemetan) 881202-45-5 5mg

JNJ-26854165 (Serdemetan CAS 881202-45-5) is a small-molecule antagonist targeting human double minute-2 (HDM-2) ubiquitin ligase originally developed as a p53 activator Mechanistically JNJ-26854165 disrupts the association between HDM-2 client protein complexes and the proteasome resulting in elevated levels of downstream HDM-2 substrates such as p53 In preclinical studies using multiple tumor models with either wild-type or mutant p53 this compound exhibited potent antiproliferative activity and apoptotic induction In vivo xenograft studies showed significant event-free survival benefits across numerous solid tumor and acute lymphoblastic leukemia models suggesting potential utility in oncology research

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6,644

Cayman Chemical SPI 112, Purity: ≥95%, CAS: 1051387-90-6, 100 mg

A cell-impermeable inhibitor of SHP-2 in cell-free assays (IC50 = 1 µM); selectively inhibits SHP-2 over SHP-1 and PTP1B (IC50s = 18.3 and 14.5 µM, respectively)

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6,645

Medchemexpress LLC Melanin probe-1 | 1420844-62-7 | MFCD32693924 | 98.1% | C12H18FN3O | 10MG

Melanin probe-1 is an 18F-picolinamide-based PET imaging probe developed for research use to image malignant melanoma. It exhibits high tumor targeting efficiency, strong tumor-to-background contrast, favorable biodistribution, and good in vivo stability, making it suitable for preclinical PET studies.

Designed for PET imaging of malignant melanoma.
High tumor targeting efficiency and strong contrast.
Favorable biodistribution and pharmacokinetics in vivo.
Good stability under biological conditions.
Provided for research use only.

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Bioactive Small Molecules

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Medchemexpress LLC Diclosulam | 145701-21-9 | 98.2% | 500 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 2,4(1H,3H)-Pyrimidinedione, 6-(octylamino)- | 83797-69-7 | 99.8% | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Soyasapogenol C | 595-14-2 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Melanin probe-1 | 1420844-62-7 | MFCD32693924 | 98.1% | C12H18FN3O | 10MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Diclosulam | 145701-21-9 | 98.2% | 500 MG

Medchemexpress LLC 2,4(1H,3H)-Pyrimidinedione, 6-(octylamino)- | 83797-69-7 | 99.8% | 50 MG

Medchemexpress LLC Soyasapogenol C | 595-14-2 | 5 MG

Medchemexpress LLC Melanin probe-1 | 1420844-62-7 | MFCD32693924 | 98.1% | C12H18FN3O | 10MG